![]() Recent research publications (March 2020–January 2021):Īnnals of the Rheumatic Diseases, January 2021–No overall increased risk of COVID-19 related death associated with current prescribed NSAID use. We have been constantly monitoring and evaluating research papers published in a broad range of scientific or academic journals around the world. For more information, please see our FAQs about managing symptoms of COVID-19. ![]() This theory regarding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) with worsening COVID-19 symptoms is without clinical evidence, and has caused considerable confusion and controversy within the medical community.īecause consumer safety and providing clear, evidence-based guidance are our priorities, we are closely monitoring independent statements from respected public health authorities and medical experts. How the controversy started A letter to the editor published in The Lancet Respiratory Medicine in March 2020 hypothesized a connection between ibuprofen and worsening symptoms of COVID-19. There is no scientific evidence that directly links the use of antipyretics/analgesics, like Advil ®, with worsened outcomes in patients suffering from COVID-19 infection. The current scientific literature does not show that antipyretics/analgesics make COVID-19 health outcomes worse, and the world’s leading health authorities have confirmed there is no evidence to recommend that COVID-19 patients avoid antipyretics/analgesics, like Advil ® (ibuprofen). The scientific consensus is clear Antipyretics/analgesics, like Advil ®, remain safe to use as directed. 1,2 People should carefully read and follow the instructions they receive at the time of COVID-19 vaccination.įor more information, please see FAQs about managing the side effects of the COVID-19 vaccine.ĭoctors and scientists agree that COVID-19 patients can use antipyretics/analgesics, like Advil ® (ibuprofen), to treat pain and reduce fever.* Advil ® is a leading over-the-counter fever and pain reliever that has been used safely and effectively for over 35 years in 40 countries.* At GSK, the makers of Advil ®, safety remains our number one priority, and we support the scientific pursuit of evidence for the safe use of Advil ®. Health authorities and scientific professional societies in the US, Canada, and Europe, including the Centers for Disease Control and Prevention (CDC), came out with a strong and consistent recommendation that antipyretics/analgesics, such as ibuprofen (Advil ®) or acetaminophen, can be taken for pain or discomfort caused by the COVID-19 vaccine. This was the case in the Pfizer-BioNTech and Moderna clinical trials, which showed efficacy of over 94%, 3,4 implying the use of antipyretics/analgesics, like ibuprofen, did not impact the immune response to the vaccine. Study participants were allowed to use antipyretics/analgesics, like ibuprofen, to treat mild side effects after injection. However, the clinical trials conducted to prove the safety and efficacy of COVID-19 vaccines offer some insight. What’s more, immune response can vary based on type of vaccine and other factors. In reality, there are limited clinical data on how antipyretics/analgesics affect the immune response to vaccines. So, you’re only really hurting yourself by taking those types of medications.” 9 Paul Offit, a member of the FDA vaccine advisory committee, said: “When you get a COVID-19 vaccine–one of these two mRNA vaccines made by Pfizer or Moderna–if you choose to take an anti-fever, anti-inflammatory medicine, know that you will probably be lessening your immune response to that vaccine. 7 The article cites a University of California Irvine Q&A advising people against taking over-the-counter (OTC) pain relievers before vaccination, but that they can be taken for symptom relief after vaccination. 3-6įollowing shortly after the availability of the COVID-19 vaccines in the US, an article published on Best Life Online made claims that ibuprofen and acetaminophen could make the COVID-19 vaccine less effective. 1,2 This is consistent with the fact that in the COVID-19 vaccine studies, participants were allowed to use antipyretics/analgesics to treat symptoms. The appropriate use of antipyretics/analgesics, like Advil ® (ibuprofen), is recommended by public health authorities to help relieve symptoms that may be experienced following vaccination. ![]() The evolving discussion around ibuprofen use and the COVID-19 vaccines ![]()
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